Mesothelioma and Cancer Gene Therapy

1 fascinating study is referred to as, “Preoperative Evaluation of Patients With Malignant Pleural Mesothelioma: Role of Integrated CT-PET Imaging” by Truong, Mylene T. MD Marom, Edith M. MD Erasmus, Jeremy J. MD – Journal of Thoracic Imaging: Could 2006 – Volume 21 – Issue two – pp 146-153 Symposia.  Here is an excerpt: “Abstract – Malignant pleural mesothelioma (MPM) is an uncommon neoplasm arising from mesothelial cells of the pleura. The prognosis is poor with a median survival of 8 to 18 months immediately after diagnosis. Multimodality regimens combining chemotherapy, radiotherapy, immunotherapy, and surgery are getting used much more often in patient management. Extrapleural pneumonectomy is the surgical therapy of choice in ten% to 15% of patients who present with resectable illness and is reported to prolong survival. Accurate staging is crucial to distinguish patients who are resectable from those requiring palliative therapy.

Integrated computed tomography-positron emission tomography (CT-PET) increases the accuracy of overall staging in patients with MPM and drastically improves the selection of patients for curative surgical resection. Particularly, CT-PET detects far more extensive illness involvement than that shown by other imaging modalities and is particularly valuable in identifying occult distant metastases. This post reviews aspects of imaging performed in the initial staging of patients with MPM according to the International Mesothelioma Interest Group staging method and will emphasize the suitable role of CT-PET imaging in determining the T, N, and M descriptors.”

Yet another study is known as, “SV40 expression in human neoplastic and non-neoplastic tissues: perspectives on diagnosis, prognosis and therapy of human malignant mesothelioma.” By Procopio A, Marinacci R, Marinetti MR, Strizzi L, Paludi D, Iezzi T, Tassi G, Casalini A, Modesti A.

Dev Biol Stand. 199894:361-7. Department of Oncology and Neuroscience, Gabriele D’Annunzio University, Chieti, Italy.  Right here is an excerpt: “Abstract – We have lately demonstrated the association of SV40 and human pleural malignant mesothelioma. Right here, we have investigated whether or not SV40 viral sequences might be linked with other human tumours or other non-neoplastic pathology and whether SV40 DNA or protein expression could be of diagnostic, prognostic or therapeutic relevance. DNA was extracted from paraffin embedded tissues. SV40, JC and BK viral sequences were detected by the polymerase chain reaction and molecular hybridization with particular probes. The screening with three various sets of SV40-connected primers demonstrated that 7/18 (38.8%) mesothelioma specimens were SV40 good as effectively as 5/18 (27.7%) tubercular pleural lesions. None of the 18 lung cancers, nor the 20 pleural non-precise inflammatory specimens tested had been positive. Twenty-5 blood samples and 18 urinary sediments from MM patients were also unfavorable. We have also located that SV40 Tag proteins are present in mesothelioma cells and tumours. Tag proteins might interfere with tumour suppressor gene goods, such as p53. Preliminary outcomes recommend that wild sort p53 transgene expression, obtained following infection with recombinant adenovirus (AdCMV.p53), inhibited in vitro and in vivo proliferation, inducing apoptosis of mesothelioma cells. Infections with manage viruses had been ineffective. As a result, SV40 DNA and Tag expression in mesothelioma tumour cells, though almost certainly not relevant for diagnostic or prognostic purposes, might be vital for innovative gene therapy tactics.”

Yet another study is known as, “Immunohistochemical reactivity in mesothelioma and adenocarcinoma: A stepwise logistic regression analysis” by Annika Dejmek, Anders Hjerpe – 1994 Acta Pathologica, Microbiologica et Immunologica Scandinavica – APMIS Volume 102, Situation 1-6, pages 255–264, January 1994.  Here is an excerpt: “Histological sections from 103 malignant mesotheliomas and 43 adenocarcinoma metastases in pleural biopsies had been investigated for reactivity against a panel of 11 various antibodies. The size of the material permitted the evaluation by stepwise logistic regression evaluation, which selected 5 parameters of major significance: vimentin reactivity in epithelial cells, reactivity to low-molecular-weight keratins in fibrous cells, strong membrane accentuation of EM A reactivity, and lack of reactivity to LeuM1 and BerEp4. 3 of these criteria had been sufficient to identify a mesothelioma with high specificity and with a sensitivity of approximately 70%. While the monoclonal anti-CEA tested was the most useful single parameter, it did not add any diagnostic info to the combination of criteria selected by the stepwise logistic regression analysis. Even so, this antibody can be used to exclude most of the adenocarcinomas from further analysis with the more extensive panel.”

If you located any of these excerpts exciting, please read the studies in their entirety.